Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG.

  title={Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG.},
  author={Yan Zhou and Wan-Jiang Zhang and Rachael M. Easton and James W Ray and Patricia A. Lampe and Zhihong Jiang and Anne L Brunkan and Alison M. Goate and Eugene Malcolm Johnson and Jane Y. Wu},
  journal={Neurobiology of disease},
  volume={9 2},
Mutations in the presenilin-1 (PS-1) gene account for a significant fraction of familial Alzheimer's disease. The biological function of PS-1 is not well understood. We report here that the proliferation-associated gene (PAG) product, a protein of the thioredoxin peroxidase family, interacts with PS-1. Microinjection of a plasmid expressing PAG into superior cervical ganglion (SCG) sympathetic neurons in primary cultures led to apoptosis. Microinjection of plasmids expressing wild-type PS-1 or… CONTINUE READING
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