Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

@article{Wong1997Presenilin1I,
  title={Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm},
  author={Philip Chuen Yung Wong and Hui Zheng and Hua Chen and Mark W. Becher and Dalip J. S. Sirinathsinghji and Myrna E. Trumbauer and Howard Y. Chen and Donald L. Price and Lex H. T. Van der Ploeg and Sangram S. Sisodia},
  journal={Nature},
  year={1997},
  volume={387},
  pages={288-292}
}
Approximately 10% of cases of Alzheimer's disease are familial and associated with autosomal dominant inheritance of mutations in genes encoding the amyloid precursor protein1, presenilin 1 (PS1)2 and presenilin 2 (PS2)3,4. Mutations in PS1 are linked to about 25% of cases of early-onset familial Alzheimer's disease5. PS1, which is endoproteolytically… CONTINUE READING