Presenilin-1 familial Alzheimer’s disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice

@article{Kiyota2015Presenilin1FA,
  title={Presenilin-1 familial Alzheimer’s disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice},
  author={Tomomi Kiyota and Christine M. Morrison and Guihua Tu and Bhagyalaxmi Dyavarshetty and Robert George Alexander Weir and Gang Zhang and Huangui Xiong and Howard E. Gendelman},
  journal={Brain, Behavior, and Immunity},
  year={2015},
  volume={49},
  pages={311-321}
}
Aberrations in hippocampal neurogenesis are associated with learning and memory, synaptic plasticity and neurodegeneration in Alzheimer's disease (AD). However, the linkage between them, β-amyloidosis and neuroinflammation is not well understood. To this end, we generated a mouse overexpressing familial AD (FAD) mutant human presenilin-1 (PS1) crossed with a knockout (KO) of the CC-chemokine ligand 2 (CCL2) gene. The PS1/CCL2KO mice developed robust age-dependent deficits in hippocampal… CONTINUE READING
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