Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its beta-catenin-binding region.

@article{Nakajima2006Presenilin1CT,
  title={Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its beta-catenin-binding region.},
  author={Mitsunari Nakajima and Minetaro Ogawa and Yuri Shimoda and Shuichi Hiraoka and Midori Iida and Haruhiko Koseki and Takuji Shirasawa and Kiyoshi Furukawa},
  journal={Cell biology international},
  year={2006},
  volume={30 3},
  pages={239-43}
}
Presenilin-1 (PS1) is a gene responsible for the development of early-onset familial Alzheimer's disease. Targeted disruption of the PS1 gene in mice suggested that PS1 might be involved in angiogenesis. We have used an in vitro embryonic stem (ES) cell culture system to prepare endothelial progenitor cells (EPC) lacking PS1 and investigated the roles of PS1 in endothelial cell lineage. With this system, Flk-1+ E-cadherin- EPC were generated from PS1-deficient ES cells, and the EPC lacking PS1… CONTINUE READING

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