Presence of the factor that inhibits collagen synthesis and stimulates cell proliferation in developing embryonic chick skin extracts.

The effects were studied of the extracts prepared from 10- and 18-day developing chick skins on collagen synthesis and proliferation of the monolayered fibroblasts established from 10-day skin. Cell proliferation was stimulated by both 10- and 18-day skin extracts at the concentration of 3.5 micrograms/ml. Collagen synthesis was suppressed by the treatment… CONTINUE READING