Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.

@article{Cario2010PresenceOT,
  title={Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.},
  author={Gunnar Cario and Martin Zimmermann and Renja Romey and Stefan Gesk and Inga Vater and Jochen Harbott and Andr{\'e} Schrauder and Anja Moericke and Shai Izraeli and Takashi Akasaka and Martin J. S. Dyer and Reiner Siebert and Martin Schrappe and Martin Stanulla},
  journal={Blood},
  year={2010},
  volume={115 26},
  pages={
          5393-7
        }
}
High-level expression of the cytokine receptor-like factor 2 gene, CRLF2, in precursor B-cell acute lymphoblastic leukemia (pB-ALL) was shown to be caused by a translocation involving the IGH@ locus or a deletion juxtaposing CRLF2 with the P2RY8 promoter. To assess its possible prognostic value, CRLF2 expression was analyzed in 555 childhood pB-ALL patients treated according to the Acute Lymphoblastic Leukemia Berlin-Frankfurt-Münster 2000 (ALL-BFM 2000) protocol. Besides CRLF2 rearrangements… CONTINUE READING
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