Presence of terminal N-acetylgalactosamineβ1-4N-acetylglucosamine residues on O-linked oligosaccharides from gastric MUC5AC: involvement in Helicobacter pylori colonization?

@article{Kenny2012PresenceOT,
  title={Presence of terminal N-acetylgalactosamineβ1-4N-acetylglucosamine residues on O-linked oligosaccharides from gastric MUC5AC: involvement in Helicobacter pylori colonization?},
  author={Diarmuid T. Kenny and Emma C Skoog and Sara K Lind{\'e}n and Weston B. Struwe and Pauline M. Rudd and Niclas G. Karlsson},
  journal={Glycobiology},
  year={2012},
  volume={22 8},
  pages={1077-85}
}
Isolation of MUC5AC mucins from the gastric mucosa from two secretor individuals (one from normal mucosa from a patient with gastric cancer and one from a control) showed different abilities to bind and induce the proliferation of the Helicobacter pylori strain J99. Analysis of the released O-linked oligosaccharides by LC-MS from these individuals showed a very heterogeneous mixture of species from the cancer patient containing both neutral and sialylated structures, whereas the normal sample… CONTINUE READING
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Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation.

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