Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation.

@article{Bellucci2011PresenceOR,
  title={Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation.},
  author={Arianna Bellucci and Orso Bugiani and Bernardino Ghetti and Maria Grazia Spillantini},
  journal={Neuro-degenerative diseases},
  year={2011},
  volume={8 4},
  pages={
          221-9
        }
}
BACKGROUND Recent findings, showing the presence of an inflammatory process in the brain of transgenic mice expressing P301S mutated human tau protein, indicate that neuroinflammation may contribute to tau-related degeneration in frontotemporal dementia and parkinsonism linked to chromosome 17 with tau mutations (FTDP-17T). OBJECTIVE To investigate the occurrence of neuroinflammatory changes in the brain of a patient affected by FTDP-17T associated with the P301S mutation and showing a… CONTINUE READING

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