Presence of preexisting antibodies mediates survival in sepsis.

  title={Presence of preexisting antibodies mediates survival in sepsis.},
  author={Rituparna Moitra and Dominic R. Beal and Bryan G. Belikoff and Daniel G Remick},
  volume={37 1},
Sepsis is one of the leading causes of death in hospitals worldwide. Even with optimal therapy, severe sepsis results in 50% mortality, indicating variability in the response of individuals towards treatment. We hypothesize that the presence of preexisting antibodies present in the blood before the onset of sepsis induced by cecal ligation and puncture (CLP) in mice accounts for the differences in their survival. A plasma-enhanced killing (PEK) assay was performed to calculate the PEK capacity… CONTINUE READING
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