Presence of polysialic acid and HNK-1 carbohydrate on brain glycoproteins from beta-1,4-galactosyltransferase-knockout mice.

@article{Kido1998PresenceOP,
  title={Presence of polysialic acid and HNK-1 carbohydrate on brain glycoproteins from beta-1,4-galactosyltransferase-knockout mice.},
  author={Masamitsu Kido and Masahide Asano and Yoichiro Iwakura and Masao Ichinose and Keisuke Miki and Kiyoshi Furukawa},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={245 3},
  pages={860-4}
}
Polysialic acid and HNK-1 carbohydrate are expressed on Gal beta 1-->4GlcNAc outer chains of N-linked sugar chain of neural cell recognition molecules at certain developmental stages and involved in neural tissue formation. Targeted inactivation of the mouse beta-1,4-galactosyltransferase (beta-1,4-GalT) gene resulted in short life of the mice which supposedly do not have such carbohydrate antigens but have no defects in neural tissue formation. Analysis of the mutant mouse brain glycoproteins… CONTINUE READING
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