Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis

@article{Costa2005PresenceOO,
  title={Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis},
  author={Cristiana E.T. da Costa and Nicola E. Annels and Claudia M.J.M. Faaij and Ramses G. Forsyth and P. C. W. Hogendoorn and R Maarten Egeler},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={201},
  pages={687 - 693}
}
Langerhans cell histiocytosis (LCH) is a disease that can involve one or multiple organ systems characterized by an accumulation of CD1a(+) Langerhans-like cells as well as several other myeloid cell types. The precise origin and role of one of these populations, the multinucleated giant cell (MGC), in this disease remains unknown. This work shows that in three different lesional tissues, bone, skin, and lymph node, the MGCs expressed the characteristic osteoclast markers, tartrate-resistant… CONTINUE READING

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