Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus.

@article{Chabre1995PresenceON,
  title={Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus.},
  author={H Chabre and Zahir Amoura and Jean Charles Piette and Pierre Godeau and J. F. Bach and Sophie Koutouzov},
  journal={Arthritis and rheumatism},
  year={1995},
  volume={38 10},
  pages={1485-91}
}
OBJECTIVE To assess whether nucleosome-restricted antibodies, i.e., antibodies that react with the whole nucleosome particle but not with its individual components (double-stranded DNA [dsDNA] and histones), are present in the sera of patients with systemic lupus erythematosus (SLE). METHODS Antibodies were detected by enzyme-linked immunosorbent assay using purified nucleosomes, dsDNA, or histones. These tests were applied to the sera of 40 patients with SLE. Protein G-purified IgGs of… CONTINUE READING