Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

@inproceedings{Irwin2015PresenceOM,
  title={Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis},
  author={Scott M. Irwin and Emily R. Driver and Edward R Lyon and Christopher Schrupp and Gavin A Ryan and Mercedes Gonzalez-Juarrero and Randall J Basaraba and Eric Nuermberger and Anne J M Lenaerts},
  booktitle={Disease models & mechanisms},
  year={2015}
}
Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of heterogeneous lesion types that reflect differences in cellular composition and organization, extent of encapsulation, and degree of caseous necrosis. C3HeB/FeJ mice have been increasingly used to model tuberculosis infection because they produce… CONTINUE READING