Presence of mesenchymal stem cells in human bone marrow after exposure to chemotherapy: evidence of resistance to apoptosis induction.

@article{Mueller2006PresenceOM,
  title={Presence of mesenchymal stem cells in human bone marrow after exposure to chemotherapy: evidence of resistance to apoptosis induction.},
  author={Lutz Peter Mueller and Jana L{\"u}tzkendorf and Thomas Mueller and Katrin Reichelt and Heike Simon and Hans-Joachim Schmoll},
  journal={Stem cells},
  year={2006},
  volume={24 12},
  pages={2753-65}
}
For various potential clinical applications, the use of autologous human MSCs (hMSCs) would be favorable. In vitro observations suggested that hMSCs are resistant for chemotherapeutic substances; however, no data exist on the characteristics of hMSCs from bone marrow (BM) of chemotherapeutically treated patients. Here, we analyzed the character of hMSCs derived from chemotherapy-exposed BM and the in vitro response of hMSCs to chemotherapeutic substances. Colony-forming units-fibroblast (CFU-Fs… CONTINUE READING

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