Presence of lorazepam in the blood plasma of drug free rats.

@article{Wildman1988PresenceOL,
  title={Presence of lorazepam in the blood plasma of drug free rats.},
  author={J M Wildman and U B Ranalder},
  journal={Life sciences},
  year={1988},
  volume={43 15},
  pages={
          1257-60
        }
}
Lorazepam has been identified in the blood plasma of non-medicated rats by means of HPLC and gas chromatography combined with mass spectrometry. It was found to be present in about 1 ng per ml blood plasma. This pharmacologically highly active compound is the first dichlorinated benzodiazepine described to occur naturally in a tissue of mammals, not treated… CONTINUE READING