Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma

@article{Brchot1980PresenceOI,
  title={Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma},
  author={Christian Br{\'e}chot and Christine Pourcel and Anne Louise and Bernadette Rain and P. Tiollais},
  journal={Nature},
  year={1980},
  volume={286},
  pages={533-535}
}
Hepatitis B virus (HBV) may be one of the agents involved in the aetiology of human primary liver cancer1. This hypothesis is supported by (1) the similarity between the geographical distribution of chronic carriers of the viral surface antigen (HBsAg) and that of hepatocellular carcinoma (HCC); (2) the increase in the prevalence of HBV markers in serum of patients with primary liver cancer when compared with the general population1; (3) the observation that HBV infection precedes the… CONTINUE READING
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