Presence of impaired insulin secretion and insulin resistance in normoglycemic male subjects with family history of type 2 diabetes.

@article{Ryder2003PresenceOI,
  title={Presence of impaired insulin secretion and insulin resistance in normoglycemic male subjects with family history of type 2 diabetes.},
  author={Elena Ryder and Mar{\'i}a Esther G{\'o}mez and Virginia Fern{\'a}ndez and Gilberto Campos and Luz Marina Morales and Humberto Alejandro Rosales Valbuena and Xiomara Raleigh},
  journal={Diabetes research and clinical practice},
  year={2003},
  volume={60 2},
  pages={
          95-103
        }
}
In order to demonstrate the effect of family history (FH) coexisting with obesity in insulin resistance (IR) and secretion in subjects at risk for type 2 diabetes, fasting and 2 h post-glucose load serum glucose and insulin concentrations were measured in 143 individuals, 66 men and 77 women, ages ranging from 18 to 68 years, who were considered at risk but were normoglycemic following ADA criteria. Insulin resistance was estimated using HOMA(IR), basal hyperinsulinemia and I(0)/G(0) ratio… 
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Hypertension and hypertriglyceridemia were better components for diagnosis of MS in obese children born large-for-gestational age and the prevalence of MS was particularly higher in obese pediatric populations born LGA.
TRABAJOS ORIGINALES RESPUESTA DE INSULINA A LA CARGA ORAL DE GLUCOSA EN NIÑOS Y ADOLESCENTES CON SOBREPESO Y OBESIDAD
TLDR
Basal insulin was significantly higher in adolescents and groups with abnormal body weight, and insulin response to an oral glucose load in children and adolescents with overweight and obesity.
Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study
TLDR
This study investigated the proportion of variance in insulin secretion and resistance accounted for by factors operating at different stages of life using a cohort of all 1142 births in the city of Newcastle, UK in May and June 1947.
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