Presence of epidermal-derived thymocyte activating factor/interleukin 1 in normal human stratum corneum.

  title={Presence of epidermal-derived thymocyte activating factor/interleukin 1 in normal human stratum corneum.},
  author={Lorise C Gahring and A W Buckley and Raymond A. Daynes},
  journal={The Journal of clinical investigation},
  volume={76 4},
Keratinocytes produce a molecule, epidermal-derived thymocyte activating factor (ETAF), which is biologically and physiochemically similar to the polypeptide hormone interleukin 1 (IL-1). Because the stratum corneum (SC) is composed of terminally differentiated keratinocytes, we questioned whether ETAF/IL-1 could be isolated from this tissue. The extraction of normal human SC with a physiologic saline solution yielded a large amount of ETAF/IL-1 activity, as measured by the in vitro thymocyte… CONTINUE READING
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