Presence of different ATP receptors on rat midbrain single synaptic terminals. Involvement of the P2X(3) subunits.

@article{DazHernndez2001PresenceOD,
  title={Presence of different ATP receptors on rat midbrain single synaptic terminals. Involvement of the P2X(3) subunits.},
  author={Miguel D{\'i}az-Hern{\'a}ndez and Rosa G{\'o}mez-Villafuertes and Francisco Javier Hernando and Jes{\'u}s Pintor and M Teresa Miras-Portugal},
  journal={Neuroscience letters},
  year={2001},
  volume={301 3},
  pages={159-62}
}
Adenosine 5'-triphosphate (ATP) stimulates a [Ca(2+)](i) increase via specific ionotropic receptors, termed P2X receptors, in rat midbrain presynaptic terminals. A microfluorimetric technique enabled study of the [Ca(2+)](i) increase in isolated single synaptic terminals, showing that 33.4+/-2.5% of them responded to ATP. Immunological studies carried out, after functional studies, with specific anti-P2X receptor subunit antibodies showed only positive labelling with anti-P2X(3) antibodies in… CONTINUE READING