Presence of angiotensin converting enzyme in the adventitia of large blood vessels

  title={Presence of angiotensin converting enzyme in the adventitia of large blood vessels},
  author={Fraser M. Rogerson and Siew Yeen Chai and Ingrid Schlawe and William K. Murray and Philip D. Marleyt and Frederick A. O. Mendelsohn},
  journal={Journal of Hypertension},
Background: Angiotensin converting enzyme (ACE) is present in the endothelial cells of all vascular beds. There are, however, many reports of converting enzyme activity in blood vessels not associated with the endothelium. Methods: ACE was localized in large blood vessels of a number of mammals by in vitro autoradiography using the radioligand 125I-351A. To characterize this binding further, immunohistochemistry was performed on rabbit aorta using polyclonal antisera raised to two different… 

Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease.

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Effects of angiotensin I and angiotensin II in blood vessels: greater influence of converting enzyme activity in the rabbit basilar artery

Evidence is provided for a greater influence of ACE in rabbit basilar artery than in peripheral vessels and in rat aorta in functional organ bath studies.

Enhanced expression of angiotensin‐converting enzyme is associated with progression of coronary atherosclerosis in humans

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Acute and chronic in vivo inhibition of angiotensin-converting enzyme by perindopril in the endothelium and adventitia of large arteries and organs of the rabbit.

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Role of endothelium in angiotensin II formation by the rat aorta and mesenteric arterial bed.

The results suggest the existence of an alternative pathway in the mesenteric arterial bed that may play an important role in Ang II generation from TDP in resistance but not in large vessels during ACE inhibition.

The cellular basis of angiotensin converting enzyme mRNA expression in rat heart

Angiotensin converting enzyme (ACE) is a key factor in the regulation of two peptide systems: the renin angiotensin system (RAS) and the kinin-kallikrein system (KKS). Since it is involved in the