Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.

  title={Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.},
  author={Tae-Wook Chun and Lieven Stuyver and Stephanie B. Mizell and Linda A. Ehler and Jo Ann M. Mican and Michael W. Baseler and Alun L. Lloyd and Martin A. Nowak and Anthony S. Fauci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 24},
Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to undetectable levels, it is unclear what the effects of these regimens are on latently infected CD4+ T cells and what role these cells play in the persistence of HIV-1 infection in individuals receiving such treatment. The present study demonstrates that highly purified CD4+ T cells from 13 of 13… CONTINUE READING
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J. K. Wong, M. Hezareh, +6 authors 1291–1295. Medical Sciences
Proc. Natl. Acad. Sci. USA 94 • 1997

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