Presence of an SH2 domain in the actin-binding protein tensin.

  title={Presence of an SH2 domain in the actin-binding protein tensin.},
  author={Stephanie Davis and Michael L. Lu and Su Hao Lo and Shuo Lin and John A. Butler and Brian J. Druker and Thomas M Roberts and Q. C. An and Lan Bo Chen},
  volume={252 5006},
The molecular cloning of the complementary DNA coding for a 90-kilodalton fragment of tensin, an actin-binding component of focal contacts and other submembraneous cytoskeletal structures, is reported. The derived amino acid sequence revealed the presence of a Src homology 2 (SH2) domain. This domain is shared by a number of signal transduction proteins including nonreceptor tyrosine kinases such as Abl, Fps, Src, and Src family members, the transforming protein Crk, phospholipase C-gamma 1, PI… CONTINUE READING


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