Presence of a truncated form of the vitamin D receptor (VDR) in a strain of VDR-knockout mice.

@article{Bula2005PresenceOA,
  title={Presence of a truncated form of the vitamin D receptor (VDR) in a strain of VDR-knockout mice.},
  author={Craig M Bula and Johanna A Huhtakangas and Christopher J Olivera and June E. Bishop and Anthony W. Norman and Helen L. Henry},
  journal={Endocrinology},
  year={2005},
  volume={146 12},
  pages={5581-6}
}
As part of our studies on the membrane-initiated actions of 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] and its localization in caveolae membrane fractions, we used a vitamin D receptor (VDR)-knockout (KO) mouse model to study the binding of [(3)H]-1alpha,25(OH)(2)D(3) in the presumed absence of the VDR. In this mouse model, known as the Tokyo strain, the second exon of the VDR gene, which encodes the first of the two zinc fingers responsible for DNA binding, was removed, and the… CONTINUE READING

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