Presence of a large molecular form of vasopressin in the fetal rat

Vasopressin (VP) and oxytocin (OT) may be synthesized in a common precursor with neurophysins (NP). We postulated that precursors may be more abundant in the neurohypophysis of the immature rat. By RIA, we found :There was a molar excess of NP early in gestation, and later a molar excess of VP. Bioassay of VP from the fetus correlated with RIA values. By… CONTINUE READING