Presence of Pancreatic Intraepithelial Neoplasia in the Pancreatic Transection Margin does not Influence Outcome in Patients with R0 Resected Pancreatic Cancer

@article{Matthaei2011PresenceOP,
  title={Presence of Pancreatic Intraepithelial Neoplasia in the Pancreatic Transection Margin does not Influence Outcome in Patients with R0 Resected Pancreatic Cancer},
  author={Hanno Matthaei and Seung-Mo Hong and Skye C. Mayo and Marco Dal Molin and Kelly L Olino and Raghunandan Venkat and Michael Goggins and Joseph M. Herman and Barish H. Edil and Christopher L. Wolfgang and John L. Cameron and Richard David Schulick and Anirban Maitra MBBS and Ralph H. Hruban},
  journal={Annals of Surgical Oncology},
  year={2011},
  volume={18},
  pages={3493-3499}
}
Margin status is one of the strongest prognosticators after resection of pancreatic ductal adenocarcinoma (PDAC). The clinical significance of pancreatic intraepithelial neoplasia (PanIN) at a surgical margin has not been established. A total of 208 patients who underwent R0 resection for PDAC between 2004 and 2008 were selected. Intraoperative frozen section slides containing the final pancreatic parenchymal transection margin were evaluated for presence or absence, number, and grade of PanINs… CONTINUE READING