Presence of HPV 16 sequences in laryngeal carcinomas.

  title={Presence of HPV 16 sequences in laryngeal carcinomas.},
  author={M. P{\'e}rez-Ayala and Francisco Javier Montes Ruiz-Cabello and Francisco Javier Frutos Esteban and Angel Concha Concha and Maximino Redondo and Maria R. Oliva and Teresa Cabrera and Federico Garrido},
  journal={International journal of cancer},
  volume={46 1},
Human papillomavirus types HPV 16 and HPV 11 DNA sequences were analyzed in normal and neoplastic tissues of the larynx, using the technique of polymerase chain reaction (PCR). An amplified region of E6 ORF was hybridized with 3' end-labelled oligonucleotide probe. Twenty six out of 48 (54%) squamous-cell carcinomas, and 3 out of 3 verrucous-cell carcinomas hybridized with HPV 16 DNA sequences, whereas we did not detect HPV 11 sequences. HPV 16 DNA sequences were also found in normal… CONTINUE READING