Presence of HLA-C-restricted cytotoxic T-lymphocyte responses in long-term nonprogressors infected with human immunodeficiency virus.

@article{Nehete1998PresenceOH,
  title={Presence of HLA-C-restricted cytotoxic T-lymphocyte responses in long-term nonprogressors infected with human immunodeficiency virus.},
  author={Pramod N Nehete and Dorothy E. Lewis and Derek Ng Tang and Marilyn S. Pollack and K Jagannadha Sastry},
  journal={Viral immunology},
  year={1998},
  volume={11 3},
  pages={119-29}
}
Approximately 5% of people with human immunodeficiency virus type 1 (HIV-1) infection remain free of disease for 10 or more years. These long-term nonprogressors (LTNPs) exhibit lower viral loads and stable CD4+ lymphocyte counts. The immunologic basis for this disease-free condition is not known. Because cytotoxic T lymphocytes (CTLs) constitute a major immune defense mechanism for sustained recovery from viral infections, we analyzed HIV-specific CTL responses in three asymptomatic LTNPs. We… CONTINUE READING
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