Presence of Endogenous PACAP-38 Ameliorated Intestinal Cold Preservation Tissue Injury

@article{Ferencz2010PresenceOE,
  title={Presence of Endogenous PACAP-38 Ameliorated Intestinal Cold Preservation Tissue Injury},
  author={Andrea Ferencz and Gyorgy Weber and Zsuzsanna Helyes and Hitoshi Hashimoto and A. Ramesha Baba and Dora Reglodi},
  journal={Journal of Molecular Neuroscience},
  year={2010},
  volume={42},
  pages={428-434}
}
Cold preservation tissue injury remains an unsolved problem during small intestinal transplantation. Pituitary adenylate cyclase-activating polypeptide (PACAP) plays a central role in the intestinal physiology. The aim of our study was to compare the cold ischemic injury in wild-type and PACAP-38 deficient mice after small bowel cold storage. Cold ischemia was produced with small bowel preservation in a University of Wisconsin solution at 4°C in wild-type (n = 35) mice for 1 h (GI), for 3 h… CONTINUE READING