Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis.

@article{Lobell1999PresenceOC,
  title={Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis.},
  author={Anna Lobell and Robert Weissert and Sana Eltayeb and Cecilia Svanholm and Tomas Olsson and Hans Wigzell},
  journal={Journal of immunology},
  year={1999},
  volume={163 9},
  pages={4754-62}
}
We here study the adjuvant properties of immunostimulatory DNA sequences (ISS) and coinjected cytokine-coding cDNA in suppressive vaccination with DNA encoding an autoantigenic peptide, myelin basic protein peptide 68-85, against Lewis rat experimental autoimmune encephalomyelitis (EAE). EAE is an autoaggressive, T1-mediated disease of the CNS. ISS are… CONTINUE READING