Presence of 5alpha-reductase isozymes and aromatase in human prostate cancer cells and in benign prostate hyperplastic tissue.

@article{NegriCesi1998PresenceO5,
  title={Presence of 5alpha-reductase isozymes and aromatase in human prostate cancer cells and in benign prostate hyperplastic tissue.},
  author={Paola Negri-Cesi and Angelo Poletti and Alessandra Colciago and Paolo Magni and Paolo Tinazzi Martini and Marcella Motta},
  journal={The Prostate},
  year={1998},
  volume={34 4},
  pages={283-91}
}
BACKGROUND Prostate trophism depends on DHT formed from T by the enzyme 5alpha-R. Two 5alpha-R isoforms with different biochemical characteristics have been cloned. Also estrogens might contribute to the prostate growth; however, their intraglandular formation by the enzyme aromatase is still debated. The aim of the present study was to verify whether (a) only one or both isoforms of the 5alpha-Rs are expressed in the prostate cancer cell line LNCaP and in BPH, or (b) the aromatase is present… CONTINUE READING

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