Presence of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, a precursor of a mutagenic nitroso compound, in soy sauce.

Abstract

After treatment with nitrite, Japanese soy sauce was strongly mutagenic to Salmonella typhimurium TA100 without S9 mixture. Two precursors of the mutagen were isolated from Japanese soy sauce, and these were identified as (-)-(1S,3S)-1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid [(-)-(1S,3S)-MTCA] and its stereoisomer (-)-(1R,3S)-MTCA. After… (More)

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@article{Wakabayashi1983PresenceO1, title={Presence of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, a precursor of a mutagenic nitroso compound, in soy sauce.}, author={K. Wakabayashi and Masaki Ochiai and H. Saito and M.. Tsuda and Yudai Suwa and M. Nagao and Tomoko Sugimura}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1983}, volume={80 10}, pages={2912-6} }