Presence and possible site of action of secretin in the rat pituitary and hypothalamus.

@article{Samson1984PresenceAP,
  title={Presence and possible site of action of secretin in the rat pituitary and hypothalamus.},
  author={Willis K Samson and Michael D. Lumpkin and S M Mccann},
  journal={Life sciences},
  year={1984},
  volume={34 2},
  pages={
          155-63
        }
}
Secretin-like immunoreactivity was detected in extracts of several rat brain structures by radioimmunoassay, most notably in the pituitary, hypothalamus, pineal and septum. Its localization to these structures suggested that it might play a role in neuroendocrine events similar to its structural homolog vasoactive intestinal peptide. Dose-related stimulations (MED, 10(-7) M) of prolactin (PRL) release were observed after incubation of synthetic secretin with dispersed, cultured pituitary cells… CONTINUE READING

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