Presence and formation of codeine and morphine in the rat.

  title={Presence and formation of codeine and morphine in the rat.},
  author={Josef Donnerer and Kazuhiro Oka and Arnold Brossi and Kenner C. Rice and Sydney Spector},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 12},
Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver somniferum, caused a marked increase in the codeine and morphine levels in rat tissues. This provides… CONTINUE READING

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