Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.

@article{Anzenbacher1998PresenceAA,
  title={Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.},
  author={Pavel Anzenbacher and Pavel Soucek and Eva Anzenbacherov{\'a} and Ivo G Gut and K Hrub{\'y} and Zbyněk Svoboda and Jaroslav Kvetina},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 1},
  pages={56-9}
}
Cytochrome P450 (CYP) of the 3A family (CYP3A) has been detected in minipig liver microsomes by immunochemical screening (Western blotting), revealing bands that co-migrate with human CYP3A4 and 3A5. The nifedipine oxidase activity and testosterone 6beta-hydroxylating activity (specific markers for CYP3A enzymes) of the human liver microsomal and minipig liver microsomal samples were comparable, as were the results of specific inhibition of this activity by triacetyloleandomycin. The presence… CONTINUE READING

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