Prereproductive stress to female rats alters corticotropin releasing factor type 1 expression in ova and behavior and brain corticotropin releasing factor type 1 expression in offspring.

@article{Zaidan2013PrereproductiveST,
  title={Prereproductive stress to female rats alters corticotropin releasing factor type 1 expression in ova and behavior and brain corticotropin releasing factor type 1 expression in offspring.},
  author={Hiba Zaidan and Micah Leshem and Inna Gaisler-Salomon},
  journal={Biological psychiatry},
  year={2013},
  volume={74 9},
  pages={680-7}
}
BACKGROUND Human and animal studies indicate that vulnerability to stress may be heritable and that changes in germline may mediate some transgenerational effects. Corticotropin releasing factor type 1 (CRF1) is a key component in the stress response. We investigated changes in CRF1 expression in brain and ova of stressed female rats and in the brain of their neonate and adult offspring. Behavioral changes in adulthood were also assessed. METHODS Adult female rats underwent chronic… CONTINUE READING
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