Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism.

@article{Roussos2008PrepulseIO,
  title={Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism.},
  author={Panos Roussos and Stella G. Giakoumaki and Maria Rogdaki and Stefanos Pavlakis and Sophia Frangou and Panos Bitsios},
  journal={Psychological medicine},
  year={2008},
  volume={38 11},
  pages={1651-8}
}
BACKGROUND Recent evidence suggests that dopamine (DA) agonist-induced disruption of prepulse inhibition (PPI) depends on basal PPI values, in a manner that suggests an inverted U-shaped relationship between PPI and prefrontal DA levels. This is the first study to examine possible genetic determinants of PPI and the catechol O-methyltransferase (COMT) Val158Met polymorphism, the main catabolic pathway of released DA in the prefrontal cortex (PFC). METHOD PPI was measured in 93 healthy males… CONTINUE READING
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