Prepulse-induced mode 2 gating behavior with and without beta-adrenergic stimulation in cardiac L-type Ca channels.

@article{Hirano1999PrepulseinducedM2,
  title={Prepulse-induced mode 2 gating behavior with and without beta-adrenergic stimulation in cardiac L-type Ca channels.},
  author={Yu Hirano and Takashi Yoshinaga and Mitsuru Murata and Masayasu Hiraoka},
  journal={The American journal of physiology},
  year={1999},
  volume={276 6 Pt 1},
  pages={C1338-45}
}
Mode 2 gating of L-type Ca channels is characterized by high channel open probability (NPo) and long openings. In cardiac myocytes, this mode is evoked physiologically in two apparently different circumstances: membrane depolarization (prepulse facilitation) and activation of protein kinase A. To examine whether the phosphorylation mechanism is involved during prepulse-induced facilitation of cardiac L-type Ca channels, we used isolated guinea pig ventricular myocytes to analyze depolarization… CONTINUE READING

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