Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.

@article{Vernet2006PrepubertalTD,
  title={Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.},
  author={Nad{\`e}ge Vernet and Christine Dennefeld and Florian Guillou and Pierre Chambon and Norbert B. Ghyselinck and Manuel Mark},
  journal={The EMBO journal},
  year={2006},
  volume={25 24},
  pages={5816-25}
}
Sertoli cells (SC) are instrumental to stem spermatogonia differentiation, a process that critically depends on retinoic acid (RA). We show here that selective ablation of RA receptor alpha (RARalpha) gene in mouse SC, singly (Rara(Ser-/-) mutation) or in combination with RARbeta and RARgamma genes (Rara/b/g(Ser-/-) mutation), abolishes cyclical gene expression in these cells. It additionally induces testis degeneration and delays spermatogonial expression of Stra8, two hallmarks of RA… CONTINUE READING