Prepubertal gynecomastia and chronic lavender exposure: report of three cases

@article{Daz2016PrepubertalGA,
  title={Prepubertal gynecomastia and chronic lavender exposure: report of three cases},
  author={Alejandro D{\'i}az and Laura Luque and Zain Badar and Steve Kornic and Marco Danon},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  year={2016},
  volume={29},
  pages={103 - 107}
}
Abstract Introduction: Prepubertal gynecomastia is a rare condition characterized by the growth of breast tissue in males as a consequence of early exposure to sexual hormones. [] Key Method Results: We studied a sample of the cologne used by one of the patients. Analysis of the chemical composition of the agua de violetas cologne was performed using high-performance liquid chromatography as well as off-line mass spectrometric detection. All these, combined with the physical appearance and the smell…

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References

SHOWING 1-10 OF 14 REFERENCES
The possible link between gynecomastia, topical lavender, and tea tree oil.
TLDR
Female PT and male prepubertal gynecomastia are lumped into a single group of “prepubertal GynecomASTia,” although most cases have been noted in females.
PREPUBERTAL AND PUBERTAL GYNECOMASTIA
TLDR
It is generally accepted that the estrogen/androgen balance is an important factor in adult gynecomastia, and some experimental evidence indicates that testosterone inhibits estrogen-induced mammary epithelial cell proliferation and suppresses estrogen receptor expression.
Epidemic of gynecomastia among haitian refugees: exposure to an environmental antiandrogen.
  • S. Brody, D. Loriaux
  • Medicine, Biology
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2003
TLDR
The antiandrogenic activity of phenothrin may explain this unusual epidemic of gynecomastia among Haitian refugees in US detention centers in 1981 and 1982.
Gynecomastia: its features, and when and how to treat it.
TLDR
A general medical history and careful physical examination with particular attention to features suggestive of breast cancer often suffice for evaluation in patients without symptoms or those with incidentally discovered breast enlargement, but men with recent-onset gynecomastia or mastodynia need a more detailed evaluation.
Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin's disease.
TLDR
Study of Ugandan boys with Hodgkin's disease confirms germ-cell depletion after combination chemotherapy and indicates further that Leydig-cell dysfunction, manifested by gynecomastia, may be a consequence of treatment in adolescent boys.
Non-classical 21-hydroxylase deficiency in boys with prepubertal or pubertal gynecomastia
TLDR
It is mandatory to suspect NC 21-OH-D in the clinical evaluation of either prepubertal or pubertal gynecomastia, since this association might be more frequent than reported so far, and it is important that diagnosis is made by the first months after gyne comastia development.
Gynecomastia: Evaluation and Treatment Recommendations for Primary Care Providers
TLDR
In most cases with physiologic gynecomastia, just reassurance and close follow-up is sufficient; however, psychologic counseling and surgical intervention may be required in few selected cases of physiologic Gynecomastsia.
Drug-induced gynecomastia in children and adolescents.
  • R. Goldman
  • Medicine
    Canadian family physician Medecin de famille canadien
  • 2010
TLDR
Adolescents who use anabolic steroids, or who abuse alcohol, marijuana, heroin, or amphetamines, should be alerted to the fact that gynecomastia might develop.
Biological activities of Lavender essential oil
TLDR
There does seem to be both scientific and clinical data that support the traditional uses of lavender, but methodological and oil identification problems have severely hampered the evaluation of the therapeutic significance of much of the research on Lavandula spp.
Prepubertal gynaecomastia: aetiology, course and outcome
background  Palpable and measurable glandular breast tissue is a rare finding in prepubertal boys and warrants thorough evaluation to rule out an underlying pathology.
...
1
2
...