Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.

@article{Cornish2007PreptinAP,
  title={Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.},
  author={Jillian Cornish and Karen E. Callon and Usha Bava and Maureen Watson and Xiufeng Xu and Jian-ming Lin and V. Chan and A Grey and Dorit Naot and Christina Maree Buchanan and Garth J S Cooper and Ian R Reid},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 1},
  pages={E117-22}
}
Several hormones that regulate nutritional status also impact on bone metabolism. Preptin is a recently isolated 34-amino acid peptide hormone that is cosecreted with insulin and amylin from the pancreatic beta-cells. Preptin corresponds to Asp(69)-Leu(102) of pro-IGF-II. Increased circulating levels of a pro-IGF-II peptide complexed with IGF-binding protein-2 have been implicated in the high bone mass phenotype observed in patients with chronic hepatitis C infection. We have assessed preptin's… CONTINUE READING