Preproinsulin mRNA engineering and its application to the regulation of insulin secretion from human hepatomas.

Abstract

Cell-based therapies for treating insulin-dependent diabetes (IDD) can provide a more physiologic regulation of blood glucose levels in a less invasive fashion than daily insulin injections. Promising cells include non-beta cells genetically engineered to secrete insulin in response to physiologic cues; responsiveness can be introduced at the… (More)

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@article{Tang2003PreproinsulinME, title={Preproinsulin mRNA engineering and its application to the regulation of insulin secretion from human hepatomas.}, author={Shiue-cheng Tang and A. Sambanis}, journal={FEBS letters}, year={2003}, volume={537 1-3}, pages={193-7} }