Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort

@article{Kuzuya2006PreproghrelinLV,
  title={Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort},
  author={M. Kuzuya and F. Ando and A. Iguchi and H. Shimokata},
  journal={International Journal of Obesity},
  year={2006},
  volume={30},
  pages={1609-1614}
}
Objective:To investigate whether Leu72Met polymorphism of the preproghrelin gene is associated with overweight/obesity in middle-aged and older Japanese.Design:Cross-sectional analysis.Subjects:A total of 2238 community-dwelling middle-aged and older Japanese people (age: 40–79 years) who participated in the first wave of examinations in the National Institute for Longevity Sciences – Longitudinal Study of Aging from April 1998 to March 2000.Measurements:The Leu72Met polymorphism of… Expand
Preproghrelin gene polymorphisms in obese Japanese: Association with diabetes mellitus in men and with metabolic syndrome parameters in women.
TLDR
SNPs in obese Japanese individuals may be predisposing factors to diabetes mellitus in men and to obesity via aberrant fat metabolism in women through preproghrelin gene polymorphisms. Expand
Preproghrelin Leu72Met polymorphism in Chinese subjects with coronary artery disease and controls.
  • N. Tang, L. Wang, +6 authors B. Wang
  • Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 2008
TLDR
The data indicate that the preproghrelin Leu72Met polymorphism is not associated with CAD in Chinese population, however, the Leu 72Met variant is associated with BMI among CAD patients. Expand
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The aim of this study was to investigate the association between the GHRL Leu72Met (rs696217) SNP with the development of T2D and serum ghrelin levels in a Western Mexican population and found a significant protective effect of the 72Met allele. Expand
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No statistically significant association was found between the ghrelin level and the Leu72Met polymorphism in preproghrelin gene with either obesity or type 2 diabetes mellitus. Expand
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The conclusion of this study is Leu72Met polymorphisms increases the risk of obesity in Javanese ethnicity, but this polymorphism does not play a role in plasma ghrelin secretion and plasma insulin secretion. Expand
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The Leu72Met polymorphism of the preproghrelin gene was not associated with T2DM in Chinese population, however, it may have some roles in the etiology of insulin resistance. Expand
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The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes.
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The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for DM2 and there is no association between the variant and atherosclerotic disease or gh Relin concentrations. Expand
The Leu72Met polymorphism of the GHRL gene prevents the development of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus
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The GHRL Leu72Met polymorphism may help to maintain normal renal function and may protect against the development of DN by reducing albuminuria and improving renal function in Chinese patients with type 2 diabetes. Expand
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