Preproenkephalin upregulation in nucleus caudalis: high and low intensity afferent stimulation differentially modulate early and late responses.

@article{Nishimori1990PreproenkephalinUI,
  title={Preproenkephalin upregulation in nucleus caudalis: high and low intensity afferent stimulation differentially modulate early and late responses.},
  author={Toshikazu Nishimori and Maria Gabriella Buzzi and Eric H. Chudler and C E Poletti and Michael A. Moskowitz and George R. Uhl},
  journal={The Journal of comparative neurology},
  year={1990},
  volume={302 4},
  pages={1002-18}
}
Nucleus caudalis expression of preproenkephalin mRNA changes following lesions depleting small-caliber primary afferent fibers and after stimulation of trigeminal afferents at different intensities. Animals treated neonatally with capsaicin display reduced preproenkephalin gene expression in nucleus caudalis neurons. Stimulation of normal animals at low intensities enhances preproenkephalin expression in a bimodal temporal pattern. High intensity stimulation is effective only at later time… CONTINUE READING