Preprandial combination of lispro and NPH insulin improves overall blood glucose control in type 1 diabetic patients: a multicenter randomized crossover trial.

@article{Annuzzi2001PreprandialCO,
  title={Preprandial combination of lispro and NPH insulin improves overall blood glucose control in type 1 diabetic patients: a multicenter randomized crossover trial.},
  author={Giovanni Annuzzi and Stefano Del Prato and Rosanna Arcari and A Bellomo Damato and Largo Rosanna Benzi and Daniela Bruttomesso and Mario Calderini and Carlo Coscelli and Domenico Fedele and Aldo Galluzzo and Mauro Giordano and Riccardo Giorgino and Annunziata Lapolla and Paola Del Basso Orsini and Gianfranco Pagano and Domenico Santoro and Gabriele Riccardi},
  journal={Nutrition, metabolism, and cardiovascular diseases : NMCD},
  year={2001},
  volume={11 3},
  pages={
          168-75
        }
}
BACKGROUND AND AIM While lispro insulin has been reported to lower postprandial blood glucose concentrations, less consistent effects have been shown for glycosylated hemoglobin (HbA1c) levels. Aim of this study was to determine whether pre-meal association of NPH, an intermediate-acting insulin, with lispro improves overall glycemic control in type 1 diabetic patients. METHODS AND RESULTS Eighty-five type 1 diabetic patients were studied in a multicenter randomized comparative (human regular… CONTINUE READING

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