Preparing to read the ubiquitin code: a middle-out strategy for characterization of all lysine-linked diubiquitins.

@article{Lee2014PreparingTR,
  title={Preparing to read the ubiquitin code: a middle-out strategy for characterization of all lysine-linked diubiquitins.},
  author={Amanda Elizabeth Lee and C A Castaneda and Yan Wang and David Fushman and Catherine Fenselau},
  journal={Journal of mass spectrometry : JMS},
  year={2014},
  volume={49 12},
  pages={
          1272-8
        }
}
Multiple studies demonstrate that ubiquitination of proteins codes for regulation of cell differentiation, apoptosis, endocytosis and many other cellular functions. There is great interest in and considerable effort being given to defining the relationships between the structures of polyubiquitin modifications and the fates of the modified proteins. Does each ubiquitin modification achieve a specific effect, much like phosphorylation, or is ubiquitin like glycosylation, where there is… CONTINUE READING
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