• DOI:10.1016/J.SEPPUR.2007.11.010
Corpus ID: 62827108

Preparative separation of ketoprofen enantiomers: choice of mobile phase composition and measurement of competitive adsorption isotherms

@article{Ribeiro2008PreparativeSO,
  title={Preparative separation of ketoprofen enantiomers: choice of mobile phase composition and measurement of competitive adsorption isotherms},
  author={Ant{\'o}nio E Ribeiro and N. Graca and L. Pais and A. Rodrigues},
  journal={Separation and Purification Technology},
  year={2008},
  volume={61},
  pages={375-383}
}

António E Ribeiro, N. Graca, +1 author A. Rodrigues

Published 2008

Chemistry

Separation and Purification Technology

The present work intends to investigate how mobile phase composition influences the adsorption behavior of ketoprofen enantiomers (a nonsteroidal anti-inflammatory drug) on an amylose-based chiral stationary phase (Chiralpak AD). Three mobile phase compositions were studied: the usual 20% ethanol/80% n-hexane mixture and two pure mobile phases; methanol and ethanol. Pulse and breakthrough experiments under preparative conditions were carried out in order to measure and test adsorption isotherms… CONTINUE READING

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