Preparative scale enantioseparation of a chiral epoxide: Comparison of liquid chromatography and simulated moving bed adsorption technology

@article{Nicoud1993PreparativeSE,
  title={Preparative scale enantioseparation of a chiral epoxide: Comparison of liquid chromatography and simulated moving bed adsorption technology},
  author={R. Nicoud and G. Fuchs and Philippe Adam and M. Bailly and E. Kuesters and F. D. Antia and Robert Reuille and E. Schmid},
  journal={Chirality},
  year={1993},
  volume={5},
  pages={267-271}
}
The feasibility of using simulated moving bed technology (SMB) for chiral separation on cellulose triacetate is demonstrated on the preparative scale: 1 kg of a chiral epoxide has been separated. On comparing SMB technology with conventional liquid chromatography it turns out that the main advantage of SMB lies in the significant reduction of mobile phase consumption. The process design for SMB is made theoretically and the predictions are confirmed by our pilot study. © 1993 Wiley-Liss, Inc. 
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