Preparation of zolmitriptan-chitosan microparticles by spray drying for nasal delivery.

@article{Alhalaweh2009PreparationOZ,
  title={Preparation of zolmitriptan-chitosan microparticles by spray drying for nasal delivery.},
  author={Amjad Alhalaweh and Staffan Andersson and Sitaram Velaga},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2009},
  volume={38 3},
  pages={206-14}
}
The objective of this study was to use spray drying to prepare mucoadhesive dry powders of the antimigraine drug, zolmitriptan, in combination with the natural polymer, chitosan, for nasal administration. The effect of type, molecular weight, and proportion of chitosan on the powder and particle characteristics was also studied. Solutions containing different proportions of chitosans were prepared and spray dried. The chemical stability and content of the drug were determined by HPLC. The… CONTINUE READING

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