Preparation of the New Bis(phenanthroline) Ligand "Clip-Phen" and Evaluation of the Nuclease Activity of the Corresponding Copper Complex.

@article{Piti1998PreparationOT,
  title={Preparation of the New Bis(phenanthroline) Ligand "Clip-Phen" and Evaluation of the Nuclease Activity of the Corresponding Copper Complex.},
  author={Marguerite Piti{\'e} and Bruno Donnadieu and Bernard Meunier},
  journal={Inorganic chemistry},
  year={1998},
  volume={37 14},
  pages={3486-3489}
}
The best nuclease activities of 1,10-phenanthroline-copper complexes have been observed for a chelate/metal stoichiometry of 2/1. To favor this stoichiometry, the "Clip-Phen" ligand was synthesized with two 1,10-phenanthroline units linked via their C2-carbons by a short flexible arm. An exogenous amine function was present to allow future vectorization of… CONTINUE READING