Preparation of submicron unilamellar liposomes by freeze-drying double emulsions.

  title={Preparation of submicron unilamellar liposomes by freeze-drying double emulsions.},
  author={Ting Wang and Yingjie Deng and Yehui Geng and Zibin Gao and Jianping Zou and Zhixuan Wang},
  journal={Biochimica et biophysica acta},
  volume={1758 2},
A novel method is described for the preparation of sterile submicron unilamellar liposomes. The method is based on the lyophilization of double emulsions containing disaccharides as lyoprotectants in both the inner and outer aqueous phase. Using various phospholipids or mixtures of lipids as emulsifiers, the double emulsions can be prepared by a two-step emulsification, including hydrophilic agents in the inner aqueous phase or lipophilic agents in the oil phase. Then, the double emulsions are… CONTINUE READING
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